Although spay and neuter surgeries in dogs are often encouraged to control overpopulation, avoid unwanted litters and prevent certain serious health conditions later in life, such as cancer, these surgeries—especially if performed at a very young age—may disrupt hormonal balance in some dogs. Known as spay-neuter syndrome (SNS), the condition can cause weight gain, anxiety and reduced vitality. For these dogs, several natural strategies can help restore hormonal balance.

Dogs’ ovaries and testes generate sex hormones such as estrogen, progesterone and testosterone, which regulate reproduction and play key roles in joint stability, metabolism, immune function, brain development and emotional regulation. When removed, the loss of hormonal feedback can disrupt many physiological systems.

A 2020 UC Davis-led analysis of 35 dog breeds found neutering before six months increased joint disorders and the risk of certain cancers, especially in larger dogs like Labradors and golden retrievers. Data from a 2013 study of more than 750 intact and neutered golden retrievers showed double the occurrence of hip dysplasia and triple the occurrence of ligament tears among early-neutered male dogs. Another study of golden retrievers in 2019 found that neutered dogs had an increased risk of obesity. Research published in 2018 involving more than 6,000 male dogs found that those allowed to mature hormonally before sterilization exhibited fewer behavioral problems like fear and aggression, underscoring the importance of natural hormone exposure in development.

Nutrition and Detoxification Support

As more dogs experience the effects of SNS, natural hormone support is increasingly important. The building blocks for hormone production come primarily from nutrients found in whole, fresh foods. Without quality proteins, healthy fats and essential vitamins and minerals, the endocrine system struggles to produce, regulate and detoxify hormones.

Feeding dogs home-cooked meals using organic, GMO-free ingredients creates a solid nutritional foundation. High-quality animal proteins like grass-fed beef and pasture-raised poultry supply amino acids needed for hormone synthesis. Organic vegetables such as leafy greens, squash and carrots offer antioxidants and micronutrients. Healthy fats from fish oil, coconut oil and flaxseed provide cholesterol and essential fatty acids, the substances from which steroid hormones are made.

Supporting a dog’s detoxification systems is just as important. The liver and gut work together to process and eliminate excess hormones and environmental toxins. Nutritional tools such as milk thistle, glutathione precursors and targeted probiotics may support these detox pathways, particularly in pets with hormonal imbalances. Additionally, natural binders like chlorella or bentonite clay are sometimes used to assist in removing certain heavy metals or persistent chemicals. However, these should be used only under professional guidance.

Glandular Therapy and Herbal Support

A 2020 review published in the journal Animals confirmed that neutering dogs leads to elevated luteinizing hormone levels, which in turn stress the thyroid, adrenal glands and immune system. This hormonal disruption can lead to chronic inflammation, behavior changes and metabolic dysfunction. Glandular supplements offer a holistic, non-pharmaceutical tool to nourish under-performing glands, especially when combined with a nutrient-rich diet and a toxin-conscious lifestyle. Bioavailable peptides, enzymes and growth factors help restore endocrine stability.

Natural herbal support may also play a role in maintaining hormonal balance. Adaptogenic herbs such as ashwagandha (Withania somnifera), rhodiola (Rhodiola rosea) and schisandra (Schisandra chinensis) have been studied in animals for their potential to modulate the stress response by regulating cortisol levels. Reproductive hormone balance may also benefit from red clover (Trifolium pratense) and chasteberry (Vitex agnus-castus). It is always important to consult with a veterinarian before introducing herbal supplements to a dog’s routine.

Lifestyle and Other Factors

Lifestyle plays a significant role in hormone balance. Daily exercise, interactive play and consistent routines help regulate stress hormones like cortisol. Chronic stress can suppress immune function and disrupt the entire hormonal cascade.Creating a toxin-conscious home is also important. 

Choose natural household cleaners, avoid synthetic air fresheners and opt for non-toxic pet care products. Providing filtered water reduces a dog’s exposure to hormone-disrupting contaminants often found in municipal supplies.

Ongoing monitoring with bloodwork, food sensitivity panels and thyroid testing helps pet parents track their dog’s progress and make informed adjustments. For dogs not yet sterilized, delaying the procedure until full maturity at 18 to 24 months or older may avoid many complications linked to early spaying and neutering.

Every dog is different. Breed, age, lifestyle and health status all play roles in determining the best course of action. Holistic veterinarians and certified pet health coaches can help design an individualized plan that supports a dog’s hormonal health naturally.

Learn more about Dr. Ruth Roberts’ approach to holistic pet care and wellness at DrRuthRoberts.com.

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